PLB/phospholamban心脏磷蛋白抗体

本公司经销PLB/phospholamban，心脏磷蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，PLB/phospholamban心脏磷蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-4197R
英文名称：Anti-PLB/phospholamban
中文名称：心脏磷蛋白抗体
其他名称：名Cardiac phospholamban; CMD1P; PLB; PLN; PPLA_HUMAN.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 25kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, cow
产品介绍：The Sarco（endo）plasmic-reticulum （SER） regulatory protein, Phospholamban （PLB）, is a small, plasma membrane-associated phospho-protein found in the SER of cardiac, smooth ａnd slow-twitch muscle. Believed to assemble into a pentamer, PLB regulates cardiac contractility ａnd Ca2+ affinity for cardiac SER Ca2+ ATPase （SERCA2a）. Non-phosphorylated PLB associates with SERCA2a, ａnd inhibits Ca2+ reuptake into the SER. PLB activation occurs when key Serine/Threonine residues in PLB （Ser-10, Ser-16, Thr-17） are phosphorylated by numerous effectors, which include PKC, PKA, PKG, ａnd CaM kinase. Phosphorylation of PLB causes dissociation from SERCA2a ａnd a subsequent increase in the rate of Ca2+ reuptake into the SER, which accelerates ventricular relaxation.Function : Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.Subcellular Location : Mitochondrion membrane. Sarcoplasmic reticulum.Tissue Specificity : Heart.Post-translational modifications : Phosphorylated in response to beta-adrenergic stimulation.DISEASE : Defects in PLN are the cause of cardiomyopathy dilated type 1P （CMD1P） [MIM:609909]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation ａnd impaired systolic function, resulting in congestive heart failure ａnd arrhythmia. Patients are at risk of premature death.Defects in PLN are the cause of cardiomyopathy familial hypertrophic type 18 （CMH18） [MIM:613874]. CMH18 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric ａnd often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, ａnd chest pain. They can be readily provoked by exercise. The disorder has inter- ａnd intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure ａnd sudden cardiac death.Similarity : Belongs to the phospholamban family.产品图片Antigen: bs-4197P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.