Pleckstrin/p47血小板47蛋白抗体

本公司经销Pleckstrin/p47，血小板47蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，Pleckstrin/p47血小板47蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-9902R
英文名称：Anti-Pleckstrin/p47
中文名称：血小板47蛋白抗体
其他名称：名p47;Platelet 47 kDa protein;Platelet ａnd leukocyte C kinase substrate;Platelet P47;Platelet p47 protein;Pleckstrin;PLEK;PLEK_HUMAN;FLJ27168;OTTHUMP00000159962.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 40kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, cow, dog
产品介绍：Platelet P47, also known as NSFL1C, UBX1, UBXD10 or UBXN2C, is a 370 amino acid protein that localizes to both the nucleus ａnd the golgi apparatus （specifically to golgi stacks） ａnd contains one SEP domain ａnd one UBX domain. Functioning as part of a ternary complex with VCP （a protein involved in the heterotypic fusion of transport vesicles with their target membranes） ａnd Syntaxin 5, p47 interacts with ａnd reduces the ATPase activity of VCP ａnd is required for the fragmentation of golgi stacks during mitosis ａnd for subsequent reassembly of golgi stacks after mitosis. p47 is subject to phosphorylation during mitosis, which inhibits p47-golgi interaction ａnd is, therefore, required for proper golgi stack formation ａnd cisternal regrowth. Human p47 shares 89% sequence identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of p47 exist due to alternative splicing events.Tissue Specificity : Major protein kinase C substrate of platelets.