PHOX2A/CFEOM2先天性眼外肌纤维化相关蛋白FEOM2抗体

本公司经销PHOX2A/CFEOM2，先天性眼外肌纤维化相关蛋白FEOM2抗体，克隆类型为polyclonal，宿主来源是Rabbit，PHOX2A/CFEOM2先天性眼外肌纤维化相关蛋白FEOM2抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-11577R
英文名称：Anti-PHOX2A/CFEOM2
中文名称：先天性眼外肌纤维化相关蛋白FEOM2抗体
其他名称：名Aristaless homeobox （Drosophila） fibrosis of extraocular muscles congenital 2 autosomal recessive;Aristaless homeobox gene homolog （Drosophila）;Aristaless homeobox homolog;Aristaless homeobox protein homolog;ARIX 1 homeodomain protein;ARIX;Arix homeodomain protein;ARIX1 homeodomain protein;CFEOM 2;CFEOM2;FEOM 2;FEOM2;Fibrosis of extraocular muscles congenital 2 autosomal recessive;MGC52227;NCAM 2;NCAM2;Paired like （aristaless） Homeobox 2A;Paired like homeobox 2a;Paired mesoderm homeobox 2a;Paired mesoderm homeobox protein 2A;Paired-like homeobox 2A;PHOX 2A;Phox2;Phox2a;PHX2A_HUMAN;Pmx 2a antibodyPmx2 antibodyPmx2a.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 29kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, Horse, dog
产品介绍：Phox2a （also designated Arix1） ａnd Phox2b are closely related, paired-homeodomain transcription factors that are necessary for neuronal differentiation throughout the developing sympathetic, parasympathetic ａnd enteric ganglia. All enteric nervous system cells evolve from the neural crest, ａnd all cells that are undifferentiated initially express Phox2b. The cells that begin to differentiate along a neuronal lineage continue to express Phox2b, ａnd begin to express Phox2a. Phox2b is required for the differentiation of all central ａnd nonperipheral noradrenergic centers in the brain. In contrast, Phox2a controls only the differentiation of the main noradrenergic center of the brain, the locus ceruleus. Both Phox2a ａnd Phox2b are crucial for the regulation of endogenous tyrosine hydroxylase ａnd dopamine-beta hydroxylase, which are transiently expressed in neural crest cells. In addition, Phox2 proteins are sufficient to promote sympathetic neuron generation. The gene which encodes Phox2a maps to human chromosome 11q13.3-q13.4. Function : May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.Subcellular Location : Nucleus.DISEASE : Defects in PHOX2A are the cause of congenital fibrosis of extraocular muscles type 2 （CFEOM2） [MIM:602078]. CFEOM encompasses several different inherited strabismus syndromes characterized by congenital restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. CFEOM is characterized clinically by anchoring of the eyes in downward gaze, ptosis, ａnd backward tilt of the head. CFEOM2 may result from the aberrant development of the oculomotor （nIII）, trochlear （nIV） ａnd abducens （nVI） cranial nerve nuclei.Similarity : Belongs to the paired homeobox family.Contains 1 homeobox DNA-binding domain.