NG2硫酸软骨素蛋白多糖4/黑色素瘤相关蛋白抗体

本公司经销NG2，硫酸软骨素蛋白多糖4/黑色素瘤相关蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，NG2硫酸软骨素蛋白多糖4/黑色素瘤相关蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-5829R
英文名称：Anti-NG2
中文名称：硫酸软骨素蛋白多糖4/黑色素瘤相关蛋白抗体
其他名称：名MELCSPG; AN2; AN2 proteoglycan; Chondroitin sulfate proteoglycan 4 （melanoma-associated）; Chondroitin sulfate proteoglycan 4; CSPG4; Cspg4 chondroitin sulfate proteoglycan 4; HMW-MAA; HSN tumor-specific antigen; MCSP; MCSPG; MEL-CSPG; Melanoma chondroitin sulfate proteoglycan; Melanoma-associated chondroitin sulfate proteoglycan; MSK16.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 251kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, hrs, Rb, dog, pig, Gpig
产品介绍：Proteoglycans （PGs） are a family of proteins composed of different polypeptide chains containing glycosaminoglycan （GAG） modifications. They vary in their cellular locations ａnd have diverse structure ａnd functions. NG2 is a proteoglycan found in the nervous system, comprising a large integral membrane PG with a core protein of 300 kDa ａnd at least one covalently attached chondroitin sulfate （CS） GAG chain. In the CNS this protein is expressed mainly on the surfaces of developing ａnd adult oligodendrocyte precursor cells, but is also associated with developing chondrocytes, cardiomyocytes, pericytes ａnd several human tumours. NG2 also stimulates alpha-4, beta-1 integrin-mediated adhesion ａnd spreading by recruiting ａnd activating a signaling cascade through CDC42, ACK1 ａnd BCAR1. May activate FAK ａnd ERK1/ERK2 signaling cascades. Subcellular Location : Apical cell membrane. Cell projection > lamellipodium membrane. Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes.Tissue Specificity : Detected only in malignant melanoma cells.Similarity : Contains 15 CSPG （NG2） repeats.Contains 2 laminin G-like domains.产品图片Antigen: bs-5829P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.