NF-L/Neurofilament L/Neurofilament 68低分子量神经丝蛋白抗体

本公司经销NF-L/Neurofilament L/Neurofilament 68，低分子量神经丝蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，NF-L/Neurofilament L/Neurofilament 68低分子量神经丝蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0707R
英文名称：Anti-NF-L/Neurofilament L/Neurofilament 68
中文名称：低分子量神经丝蛋白抗体
其他名称：名Neurofilament triplet L; 70 kD Neurofilament Light; 68kDa neurofilament protein; CMT 1F; CMT 2E; CMT1F; CMT2E; FLJ53642; Light molecular weight neurofilament protein; NEFL; Neurofilament light; Neurofilament light polypeptide 68kDa; Neurofilament light polypeptide; Neurofilament protein, light chain; Neurofilament subunit NF L; Neurofilament triplet L protein; NF 68; NF L; NF68; NFL.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 68kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Neurofilament light polypeptide also called NF-L; Neurofilament triplet L protein; 68 kDa neurofilament protein. Neurofilaments usually contain three intermediate filament proteins: L, M, ａnd H which are involved in the maintenance of neuronal caliber. The extra mass ａnd high charge density that distinguish the neurofilament proteins from all other intermediate filament proteins are due to the tailpiece extensions. This region may form a charged scaffolding structure suitable for interaction with other neuronal components or ions. NF-L is the most abundant of the three neurofilament proteins and, as the other nonepithelial intermediate filament proteins, it can form homopolymeric 10-nm filaments. Belongs to the intermediate filament family.Function : Neurofilaments usually contain three intermediate filament proteins: L, M, ａnd H which are involved in the maintenance of neuronal caliber.Subunit : Interacts with ARHGEF28 （By similarity）. Interacts with TRIM2 （By similarity）.Post-translational modifications : O-glycosylated （By similarity）.Phosphorylated in the head ａnd rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.Ubiquitinated in the presence of TRIM2 ａnd UBE2D1 （By similarity）.DISEASE : Defects in NEFL are the cause of Charcot-Marie-Tooth disease type 1F （CMT1F） [MIM:607734]. CMT1F is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties ａnd histopathology: primary peripheral demyelinating neuropathy or CMT1, ａnd primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities （less than 38 m/sec）, segmental demyelination ａnd remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy ａnd weakness, absent deep tendon reflexes, ａnd hollow feet. CMT1F is characterized by onset in infancy or childhood （range 1 to 13 years）.Defects in NEFL are the cause of Charcot-Marie-Tooth disease type 2E （CMT2E） [MIM:607684]. CMT2E is an autosomal dominant form of Charcot-Marie-Tooth disease type 2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, ａnd progressive distal muscle weakness ａnd atrophy.Similarity : Belongs to the intermediate filament family.神经生物学相关蛋白（Neurobiology） 低分子量神经丝蛋白,简称NF-L,分子量为68kDa，NF-L的聚集与神经退行性疾病的发病机理相关，如运动神经元的降解等。 神经纤丝蛋白的功能是提供弹性使神经纤维易于伸展和防止断裂。 神经丝是中间纤维的一种重要类型又称神经微丝蛋白，特异地在神经细胞内表达，并在轴突内相互平行排列成束.　哺乳动物的神经丝由3种蛋白组成： 低分子量神经丝蛋白，简称NF-L；分子量为68kDa； 中分子量神经丝蛋白，简称NF-M；分子量为160kDa； 高分子量神经丝蛋白，简称NF-H，分子量为200 kDa。