HDAC1 Human/ 重组人组蛋白脱乙酰基酶1_详细资料

产品信息 HDAC1 Human/ 重组人组蛋白脱乙酰基酶1 慧嘉生物您实验身边的好伙伴 为客户提供“品质的产品”和“质的服务” AssayBiotech CUSABIO   Immunoway Santa   Abcam   Cst   jackson   Pierce Sigma Amresco Qiagen Cayman abnova millipore invitrogen merk ebioscience prospec lifespan BD 欢迎广大客户咨询，另有大量宣传海报和小礼品赠送。 网站：www.biohj.com Q Q：382603320   1284882975 HDAC1 Human/ 重组人组蛋白脱乙酰基酶1 产品编号：ENZ-424 产品规格：5μg/20μg/1mg Synonyms HD1, RPD3, GON-10, RPD3L1, DKFZp686H12203, HDAC1, Histone deacetylase 1. Introduction HDAC1 is a member of the histone deacetylase/acuc/apha family ａnd a component of the histone deacetylase complex. HDAC1 is in charge of the deacetylation of lysine residues on the N-terminal part of the core histones （H2A, H2B, H3 ａnd H4）. Histone acetylation ａnd deacetylation, catalyzed by multi-subunit complexes, are a crucial factor in the regulation of eukaryotic gene expression. In addition, HDAC1 interacts with retinoblastoma tumor-suppressor protein ａnd this complex is a major factor in the control of cell proliferation ａnd differentiation. Low levels of HDAC1 were linked to breast cancer progression. Studies have shown that cancer cells successfully maintained decreased levels of pyruvate to prevent inhibition of HDAC1/HDAC3 ａnd thus to escape cell death. HDAC1 is over-expressed in diffuse large B-cell lymphoma ａnd peripheral T-cell lymphoma in opposite to normal lymphoid tissue. The tissue specificity of HDAC1 is ubiquitous, with higher levels in the heart, pancreas ａnd testis, ａnd lower levels in the kidney ａnd brain. Description HDAC1 Human Recombinant fused with 8 amino acid His tag at C-terminus produced in Hi-5 is a single, glycosylated, polypeptide chain containing 490 amino acids （1-482 a.a.）ａnd having a molecular mass of 56.2 kDa. The HDAC1 is purified by proprietary chromatographic techniques. Source Hi-5 Baculovirus. Physical Appearance Sterile Filtered colorless solution. Formulation The HDAC1 solution contains PBS （pH 7.4）ａnd 10% glycerol. Stability HDAC1 although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles. Purity Greater than 90.0% as determined by（a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE. Amino acid sequence MAQTQGTRRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIYRPHKAN AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSTGGSVAS AVKLNKQQTD IAVNWAGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV LYIDIDIHHG DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI FKPVMSKVME MFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE KIKQRLFENL RMLPHAPGVQ MQAIPEDAIP EESGDEDEDD PDKRISICSS DKRIACEEEF SDSEEEGEGG RKNSSNFKKA KRVKTEDEKE KDPEEKREVT EEEKTKEEKP EAKGVKEEVK LASRHHHHHH. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Synonyms	HD1, RPD3, GON-10, RPD3L1, DKFZp686H12203, HDAC1, Histone deacetylase 1.
Introduction	HDAC1 is a member of the histone deacetylase/acuc/apha family ａnd a component of the histone deacetylase complex. HDAC1 is in charge of the deacetylation of lysine residues on the N-terminal part of the core histones （H2A, H2B, H3 ａnd H4）. Histone acetylation ａnd deacetylation, catalyzed by multi-subunit complexes, are a crucial factor in the regulation of eukaryotic gene expression. In addition, HDAC1 interacts with retinoblastoma tumor-suppressor protein ａnd this complex is a major factor in the control of cell proliferation ａnd differentiation. Low levels of HDAC1 were linked to breast cancer progression. Studies have shown that cancer cells successfully maintained decreased levels of pyruvate to prevent inhibition of HDAC1/HDAC3 ａnd thus to escape cell death. HDAC1 is over-expressed in diffuse large B-cell lymphoma ａnd peripheral T-cell lymphoma in opposite to normal lymphoid tissue. The tissue specificity of HDAC1 is ubiquitous, with higher levels in the heart, pancreas ａnd testis, ａnd lower levels in the kidney ａnd brain.
Description	HDAC1 Human Recombinant fused with 8 amino acid His tag at C-terminus produced in Hi-5 is a single, glycosylated, polypeptide chain containing 490 amino acids （1-482 a.a.）ａnd having a molecular mass of 56.2 kDa. The HDAC1 is purified by proprietary chromatographic techniques.
Source	Hi-5 Baculovirus.
Physical Appearance	Sterile Filtered colorless solution.
Formulation	The HDAC1 solution contains PBS （pH 7.4）ａnd 10% glycerol.
Stability	HDAC1 although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
Purity	Greater than 90.0% as determined by（a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE.
Amino acid sequence	MAQTQGTRRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIYRPHKAN AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSTGGSVAS AVKLNKQQTD IAVNWAGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV LYIDIDIHHG DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI FKPVMSKVME MFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE KIKQRLFENL RMLPHAPGVQ MQAIPEDAIP EESGDEDEDD PDKRISICSS DKRIACEEEF SDSEEEGEGG RKNSSNFKKA KRVKTEDEKE KDPEEKREVT EEEKTKEEKP EAKGVKEEVK LASRHHHHHH.
Usage	ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.