MicrotubuleYZ剂：MMAE（一甲基澳瑞他汀E）定制供应474645-27-7

 

 

 

 

 

中文名称：一甲基澳瑞他汀E 

中文别名：MicrotubuleYZ剂 

英文名称：[3H]-Vedotin 

英文别名：monomethylauristatinE; Monomethylauristatin E; MonoMethyl auristatin E; 

CAS号：474645-27-7 

分子式：C39H67N5O7 

分子量：717.97900 

精确质量：717.50400 PSA：149.54000 LogP：4.64040

 

简介：

Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro ａnd in vivo, against a range of lymphomas, leukemia ａnd solid tumors. These drugs show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as other types of cancer.

MMAE is actually desmethyl-auristatin E; that is, the N-terminal amino group has only one methyl substituent instead of two as in auristatin E itself.
 

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