Arg-Gly-Asp 99896-85-2 RGD肽

RGD肽

分子式：C12H22N6O6    分子量：346.34

 

 

产品描述

RGD (Arg-Gly-Asp) 多肽是一种细胞粘附序列，可以模仿细胞粘附蛋白并与整合素结合。

靶点

           

IC50

           

体外研究

The RGD sequence is the cell attachment site of a large number of adhesive extracellular matrix, blood, ａnd cell surface proteins, ａnd nearly half of the over 20 known integrins recognize this sequence in their adhesion protein ligands. The RGD peptides ａnd mimics can be used to probe integrin functions in various biological systems. Drug design based on the RGD structure may provide new treatments for diseases such as thrombosis, osteoporosis, ａnd cancer.RGD peptide acts as an inhibitor of integrin-ligand interactions ａnd can induce apoptosis in the absence of signals ａnd integrin-mediated cell clustering. Research demonstrates that RGD peptides promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation ａnd autoprocessing.The RGD peptide can serve as a cell adhesion site of extracellular matrix, cell surface proteins, ａnd integrins. In addition, RGD peptide can inhibit ACK-2 activation through cell adhesion.

体内研究

 

溶解性

水 100 mM

稳定性

2年 -20°C粉状，6月-80°C溶于DMSO