99896-85-2 Arg-Gly-Asp 99896-85-2RGD肽

Arg-Gly-Asp 99896-85-2RGD肽

RGD肽
分子式：C12H22N6O6    分子量：346.34
 
 
产品描述
RGD (Arg-Gly-Asp) 多肽是一种细胞粘附序列，可以模仿细胞粘附蛋白并与整合素结合。
靶点
           
IC50
           
体外研究
The RGD sequence is the cell attachment site of a large number of adhesive extracellular matrix, blood, and cell surface proteins, and nearly half of the over 20 known integrins recognize this sequence in their adhesion protein ligands. The RGD peptides and mimics can be used to probe integrin functions in various biological systems. Drug design based on the RGD structure may provide new treatments for diseases such as thrombosis, osteoporosis, and cancer.RGD peptide acts as an inhibitor of integrin-ligand interactions and can induce apoptosis in the absence of signals and integrin-mediated cell clustering. Research demonstrates that RGD peptides promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing.The RGD peptide can serve as a cell adhesion site of extracellular matrix, cell surface proteins, and integrins. In addition, RGD peptide can inhibit ACK-2 activation through cell adhesion.
体内研究
 
溶解性
水 100 mM
稳定性
2年 -20°C粉状，6月-80°C溶于DMSO