Prospec PRO-383 ICAM-1 Human/重组人细胞间粘附分子- 1_详细资料

产品信息

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ICAM-1 Human/重组人细胞间粘附分子- 1
产品编号：PRO-383
产品规格：2μg/10μg/1mg

Synonyms Intercellular adhesion molecule 1, ICAM-1, Major group rhinovirus receptor, CD54 antigen, ICAM1, BB2, CD54, P3.58.

Introduction ICAM-1 also called CD54 is a single chain membrane glycoprotein expressed on the surface of a variety of non-haematopoietic ａnd haematopoietic cell types ａnd has roles in signal transduction, cell signaling ａnd lymphocyte adhesion. ICAM1 binds to integrins such as CD11a / CD18, or CD11b / CD18. ICAM1 is also used by Rhinovirus as a receptor. ICAM-1 is an intercellular adhesion molecule constantly present in low concentrations in the membranes of leukocytes ａnd endothelial cells. When stimulated by cytokine the concentrations significantly increase. ICAM-1 can be stimulated by interleukin-1 （IL-1）ａnd tumor necrosis factor alpha （TNF?）ａnd is expressed by the vascular endothelium, macrophages ａnd lymphocytes. ICAM-1 is a ligand for LFA-1 which is a receptor found on leukocytes. Upon activation, leukocytes bind to endothelial cells via ICAM-1/LFA-1 ａnd then transmigrate into tissues.
ICAM-1 is implicated in subarachnoid hemorrhage （SAH）. Levels of ICAM-1 are shown to be notably elevated in patients with SAH.
Soluble ICAM-1 is detectable in the plasma ａnd is elevated in patients with various inflammatory conditions.

Description ICAM-1 Human Recombinant is expressed in E. coli containing 455 amino acids 28-483 fused to an amino terminal hexahistidine tag.
The ICAM-1 is purified by proprietary chromatographic techniques.

Source Escherichia Coli.

Physical Appearance Sterile Filtered clear solution.

Formulation ICAM-1 is supplied （0.2mg/ml） in PBS, 50% Glycerol, 2mM Imidazole.

Application ICAM-I can be used directly as a positive control in Western blotting, ELISA, immunoprecipitation ａnd other immunological experiments.
The biological activity of this product has not yet been tested.

Storage Conditions Store at 4°C if entire vial will be used within 1-2 weeks.
Store, frozen at -20°C for longer periods of time.
Avoid multiple freeze-thaw cycles.

Purity Greater than 95% as determined by SDS-PAGE.

Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Synonyms	Intercellular adhesion molecule 1, ICAM-1, Major group rhinovirus receptor, CD54 antigen, ICAM1, BB2, CD54, P3.58.
Introduction	ICAM-1 also called CD54 is a single chain membrane glycoprotein expressed on the surface of a variety of non-haematopoietic ａnd haematopoietic cell types ａnd has roles in signal transduction, cell signaling ａnd lymphocyte adhesion. ICAM1 binds to integrins such as CD11a / CD18, or CD11b / CD18. ICAM1 is also used by Rhinovirus as a receptor. ICAM-1 is an intercellular adhesion molecule constantly present in low concentrations in the membranes of leukocytes ａnd endothelial cells. When stimulated by cytokine the concentrations significantly increase. ICAM-1 can be stimulated by interleukin-1 （IL-1）ａnd tumor necrosis factor alpha （TNF?）ａnd is expressed by the vascular endothelium, macrophages ａnd lymphocytes. ICAM-1 is a ligand for LFA-1 which is a receptor found on leukocytes. Upon activation, leukocytes bind to endothelial cells via ICAM-1/LFA-1 ａnd then transmigrate into tissues. ICAM-1 is implicated in subarachnoid hemorrhage （SAH）. Levels of ICAM-1 are shown to be notably elevated in patients with SAH. Soluble ICAM-1 is detectable in the plasma ａnd is elevated in patients with various inflammatory conditions.
Description	ICAM-1 Human Recombinant is expressed in E. coli containing 455 amino acids 28-483 fused to an amino terminal hexahistidine tag. The ICAM-1 is purified by proprietary chromatographic techniques.
Source	Escherichia Coli.
Physical Appearance	Sterile Filtered clear solution.
Formulation	ICAM-1 is supplied （0.2mg/ml） in PBS, 50% Glycerol, 2mM Imidazole.
Application	ICAM-I can be used directly as a positive control in Western blotting, ELISA, immunoprecipitation ａnd other immunological experiments. The biological activity of this product has not yet been tested.
Storage Conditions	Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Purity	Greater than 95% as determined by SDS-PAGE.
Usage	ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.