ICC1311 Aurora A Inh Aurora A Inh_详细资料

产品信息

ICC1311 Aurora A Inhibitor I
Aurora A Inhibitor I，>98%
【英文同义名】：Aurora-A Inhibitor I, Aurora-A-inhibitor-I
订购信息：（原装进口，常备现货）
品 Pai
产品名称
产品货号
规格
目录价（元）
Gene Operation
ibitor I
ICC1311-0005MG
5 mg
¥979.00
ICC1311-0010MG
10 mg
¥1,749.00
ICC1311-0050MG
50 mg
¥5,429.00

产品描述
ibitor I是一种Aurora A选择性YZ剂，其作用Arurora A( IC50为3.4 nM)比作用于Aurora B( IC50为3.4 µM)选择性高1000倍。ibitor I可YZHCT116和HT29细胞系的增殖。研究表明其作用效果差异在于ibitor I偏爱Aurora A 的Thr217位点，该氨基酸是结合ibitor I的关键氨基酸，而不可以结合到Aurora B 相应的Glu161位点^[1]。ibitor I使KCL-22细胞在G2/M期累积，但是不会诱导产生多倍体。ibitor I 诱导组蛋白H3在 serine 10位点磷酸化，且YZAurora A 在threonine 288位点自磷酸化^[2]。
靶点
靶点
Aurora A
Aurora B
IC₅₀（半数有效浓度）
3.4nM
3.4µM^[1]
化学特性
Cas No.: 1158838-45-9
M. Wt.: 88.07
Formula: C₃₁H₃₁ClFN₇O₂
Purity: >98%
Synonym: Aurora-A Inhibitor I, Aurora-A-inhibitor-I
Chemical Name:
N-(2-chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide
Appearance: white to beige powder
Solubility: Soluble in DMSO (10mg/ml)
Storage：Store powder at -20 ºC for the stability of two years.
储存液配制
储存液 (1 ml DMSO体系)
1mM
5mM
10mM
15mM
质量(mg)
0.5881
2.9404
5.8807
8.8211
结构式使用浓度(仅作参考)
ibitor I的具体使用浓度请参考相关文献，并根据自身实验条件（如实验目的，细胞种类，培养特性等）进行摸索和优化。
参考文献
[1] Martin L A , et al. A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J Med Chem.52(10):3300-7(2009) .
[2] Hong feng Yuan, et al. Overcoming CML acquired resistance by specific inhibition of Aurora A kinase in the KCL-22 cell model. Carcinogenesis. 33(2): 285–293(2012).

您可能感兴趣的产品

ICC1311 Aurora A Inh Aurora A Inh

产品信息

联系我们

关注我们

品 Pai	产品名称	产品货号	规格	目录价（元）
Gene Operation	ibitor I	ICC1311-0005MG	5 mg	¥979.00
		ICC1311-0010MG	10 mg	¥1,749.00
		ICC1311-0050MG	50 mg	¥5,429.00

靶点	Aurora A	Aurora B
IC₅₀（半数有效浓度）	3.4nM	3.4µM^[1]

Cas No.: 1158838-45-9	M. Wt.: 88.07
Formula: C₃₁H₃₁ClFN₇O₂	Purity: >98%
Synonym: Aurora-A Inhibitor I, Aurora-A-inhibitor-I
Chemical Name: N-(2-chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide
Appearance: white to beige powder
Solubility: Soluble in DMSO (10mg/ml)
Storage：Store powder at -20 ºC for the stability of two years.

储存液 (1 ml DMSO体系)	1mM	5mM	10mM	15mM
质量(mg)	0.5881	2.9404	5.8807	8.8211