LEUPEPTIN 亮抑酶肽 Acetyl-Leu-Leu-Arg-..._详细资料

产品信息

LEUPEPTIN 亮抑酶肽

Structure:

Hemisulfate

Trifluoroacetate Salt

Hydrochloride

Molecular Formula

C₂₀H₃₈N₆O₄·½H₂SO₄

C₂₀H₃₈N₆O₄·C₂HF₃O₂

C₂₀H₃₈N₆O₄·HCl

Molecular Weight

475.6

540.6

463.0

CAS #

103476-89-7

147385-61-3

24125-16-4

Synonym: Acetyl-Leu-Leu-Arg-al
Physical Description: White to off-white powder
Solubility: Soluble in water （50 mg/ml-clear, faint yellow solution）. Stock solutions of 10 mM in water are stable for 1 week at 4°C and 1 month if aliquoted and stored at -20°C. Stock solutions can then be diluted 1:100 to make a 100 uM working solution. Working solutions are stable for only a few hours.
Description: A modified tripeptide reversible protease inhibitor of trypsin-like proteases and some cysteine proteases including endoproteinase Lys-C, kallikrein, papain, thrombin, cathepsin B, cathepsins H and L, trypsin, calpain, trypsin and plasmin. Effective concentration is typically 10-100 uM. Little to no inhibition is seen against pepsin, cathepsins A and D and alpha-chymotrypsin. When adjusted for molarity, all three salt forms are equally effective; however, the hydrochloride salt is usually less invasive in biological settings.
Leupeptin, because of its aldehyde group, may act as a reducing agent and therefore interfere in protein determinations such as Lowry and, to a lesser extent, Bradford.
Note: Leupeptin gives multiple peaks on HPLC due to equilibria among three forms in solution. Purity determined by HPLC should take into account the three main peaks. Majority of contaminating peptide is racemized leupeptin.
The primary mechanism of inactivation is racemization of the L-arginal; the D-arginal form is totally inactive. If the aldehyde is oxidized but retains its L-configuration, the resulting compound does have some inhibitory activity.
Ordering Information：

货号

名称

产地

规格

报价/元

特价/元

LEUPEPTIN 亮抑酶肽

MPBIO

5mg

823

280

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Hemisulfate	Trifluoroacetate Salt	Hydrochloride
Molecular Formula	C₂₀H₃₈N₆O₄·½H₂SO₄	C₂₀H₃₈N₆O₄·C₂HF₃O₂	C₂₀H₃₈N₆O₄·HCl
Molecular Weight	475.6	540.6	463.0
CAS #	103476-89-7	147385-61-3	24125-16-4

货号	名称	产地	规格	报价/元	特价/元
	LEUPEPTIN 亮抑酶肽	MPBIO	5mg	823	280