Human VEGF-D/重组人血管内生长因子-D
产品编号:100-374
产品规格:10μg
Description: VEGF-D, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymph angiogenesis, and can also affect vascular permeability. VEGF-D is highly expressed in the lung, heart, small intestine and fetal lung, and at lower levels in the skeletal muscle, colon, and pancreas. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-D may play a role in the formation of the venous and lymphatic vascular systems. It also participates in the growth and maintenance of differentiated lymphatic endothelium in adults. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant human VEGF-D is a 13.1 kDa non-disulfide linked homodimeric protein consisting of two 117 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.
Source: 293 cells
Molecular Weight: 20-22 kDa
Purity: >95% by SDS-PAGE and HPLC analysis
Endotoxin level/内毒素水平: < 0.1 ng per μg of VEGF-D
Formulation: lyophilized
Biological Activity: Test in progress!
Stability: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted human VEGF-D should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
Usage: Human VEGF-D is offered for research use. Not for drug use. Not for human use.