标准品渥曼青霉素/沃氏篮素/Wortmannin/WT_详细资料

产品信息

渥曼青霉素/沃氏篮素/Wortmannin/WT

Source: Wortmanin is produced by the fungus Talaromyces （Penicillium） wortmannii

Synonyms BRN 0067676
NSC 627609
Antibiotic SL-2052
Wartmannin
Wortmannin
KY 12420
Systematic Name
（1alpha,11alpha）-11-（Acetyloxy）-1-（methoxymethyl）-2-oxaandrosta-5,8-dieno（6,5,4-bc）furan-3,7,17-trione

Description: Wortmannin is an antifungal antibiotic, similar to viridin.

CAS number: 19545-26-7

Merck index: 12, 10188

Molecular weight: 428.44

Structure:

Molecular Formula: C₂₃H₂₄O₈

Solubility
information: DMSO, Methanol. Unstable in aqueous and ethanolic solutions.

Specifications

Appearance: Off-white to pale yellow powder

Purity: At least 97.5% by TLC, HPLC

λ_max: 210-220, 256, 293 （not a part of specification）

Melting point 240^oC +- 2^oC. not a part of specification

Solubility Clear colorless solution at 5 mg/ml Methanol.

Storage -20°C .Hygroscopic. Protect from light and moisture.

Applications Wortmannin is an inhibitor of phosphatidyl-inositol 3-kinase
Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase.
Wortmannin inhibits repair of DNA double-strand breaks in irradiated normal human cells. Wortmannin was shown to have enhancing influence on memory and impair learning abilities.

Warnings
POTENTIALLY FATAL IF SWALLOWED, INHALLED OR ABSORBED THROUGH SKIN.

Classification chemical class:Androstadiene
phospholipase D inhibitor. Immunosupressor. Antifungal.

Related products

For Research use only. Not for Human or Drug use
GMP/API grade

No genetically modified organisms are used.

Publications Yuan H, Luo J, Weissleder R, Cantley L, Josephson L.
Wortmannin-C20 conjugates generate wortmannin.
J Med Chem. 2006 Jan 26;49（2）:740-7.

Nakipova OV, Andreeva LA, Zakharova NM, Semenova TP, Solomonov NG.
Influence of wortmannin on the inotropic effect of insulin in papillary muscles of Siberian ground squirrel heart.
Dokl Biochem Biophys. 2006 Mar-Apr;407:91-3

Zhu T, Gu J, Yu K, Lucas J, Cai P, Tsao R, Gong Y, Li F, Chaudhary I, Desai P, Ruppen M, Fawzi M, Gibbons J, Ayral-Kaloustian S, Skotnicki J, Mansour T, Zask A.
Pegylated wortmannin and 17-hydroxywortmannin conjugates as phosphoinositide 3-kinase inhibitors active in human tumor xenograft models.
J Med Chem. 2006 Feb 23;49（4）:1373-8.

Hazeki K, Kinoshita S, Matsumura T, Nigorikawa K, Kubo H, Hazeki O.
Opposite effects of wortmannin and 2-（4-morpholinyl）-8-phenyl-1（4H）-benzopyran-4-one hydrochloride on toll-like receptor-mediated nitric oxide production: negative regulation of nuclear factor-{kappa}B by phosphoinositide 3-kinase.
Mol Pharmacol. 2006 May;69（5）:1717-24.

Giner JL, Kehbein KA, Cook JA, Smith MC, Vlahos CJ, Badwey JA.
Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinase.
Bioorg Med Chem Lett. 2006 May 1;16（9）:2518-21.

Sullivan JA, Grummer MA, Yi FX, Bird IM.
Pregnancy-enhanced endothelial nitric oxide synthase （eNOS） activation in uterine artery endothelial cells shows altered sensitivity to Ca2+, U0126, and wortmannin but not LY294002--evidence that pregnancy adaptation of eNOS activation occurs at multiple levels of cell signaling.
Endocrinology. 2006 May;147（5）:2442-57

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Source:	Wortmanin is produced by the fungus Talaromyces （Penicillium） wortmannii
Synonyms	BRN 0067676 NSC 627609 Antibiotic SL-2052 Wartmannin Wortmannin KY 12420 Systematic Name （1alpha,11alpha）-11-（Acetyloxy）-1-（methoxymethyl）-2-oxaandrosta-5,8-dieno（6,5,4-bc）furan-3,7,17-trione
Description:	Wortmannin is an antifungal antibiotic, similar to viridin.
CAS number:	19545-26-7
Merck index:	12, 10188
Molecular weight:	428.44
Structure:
Molecular Formula:	C₂₃H₂₄O₈
Solubility information:	DMSO, Methanol. Unstable in aqueous and ethanolic solutions.
Specifications
Appearance:	Off-white to pale yellow powder
Purity:	At least 97.5% by TLC, HPLC
λ_max:	210-220, 256, 293 （not a part of specification）
Melting point	240^oC +- 2^oC. not a part of specification
Solubility	Clear colorless solution at 5 mg/ml Methanol.
Storage	-20°C .Hygroscopic. Protect from light and moisture.
Applications	Wortmannin is an inhibitor of phosphatidyl-inositol 3-kinase Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase. Wortmannin inhibits repair of DNA double-strand breaks in irradiated normal human cells. Wortmannin was shown to have enhancing influence on memory and impair learning abilities.
Warnings	POTENTIALLY FATAL IF SWALLOWED, INHALLED OR ABSORBED THROUGH SKIN.
Classification	chemical class:Androstadiene phospholipase D inhibitor. Immunosupressor. Antifungal.
Related products
	For Research use only. Not for Human or Drug use GMP/API grade No genetically modified organisms are used.
Publications	Yuan H, Luo J, Weissleder R, Cantley L, Josephson L. Wortmannin-C20 conjugates generate wortmannin. J Med Chem. 2006 Jan 26;49（2）:740-7.
	Nakipova OV, Andreeva LA, Zakharova NM, Semenova TP, Solomonov NG. Influence of wortmannin on the inotropic effect of insulin in papillary muscles of Siberian ground squirrel heart. Dokl Biochem Biophys. 2006 Mar-Apr;407:91-3
	Zhu T, Gu J, Yu K, Lucas J, Cai P, Tsao R, Gong Y, Li F, Chaudhary I, Desai P, Ruppen M, Fawzi M, Gibbons J, Ayral-Kaloustian S, Skotnicki J, Mansour T, Zask A. Pegylated wortmannin and 17-hydroxywortmannin conjugates as phosphoinositide 3-kinase inhibitors active in human tumor xenograft models. J Med Chem. 2006 Feb 23;49（4）:1373-8.
	Hazeki K, Kinoshita S, Matsumura T, Nigorikawa K, Kubo H, Hazeki O. Opposite effects of wortmannin and 2-（4-morpholinyl）-8-phenyl-1（4H）-benzopyran-4-one hydrochloride on toll-like receptor-mediated nitric oxide production: negative regulation of nuclear factor-{kappa}B by phosphoinositide 3-kinase. Mol Pharmacol. 2006 May;69（5）:1717-24.
	Giner JL, Kehbein KA, Cook JA, Smith MC, Vlahos CJ, Badwey JA. Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinase. Bioorg Med Chem Lett. 2006 May 1;16（9）:2518-21.
	Sullivan JA, Grummer MA, Yi FX, Bird IM. Pregnancy-enhanced endothelial nitric oxide synthase （eNOS） activation in uterine artery endothelial cells shows altered sensitivity to Ca2+, U0126, and wortmannin but not LY294002--evidence that pregnancy adaptation of eNOS activation occurs at multiple levels of cell signaling. Endocrinology. 2006 May;147（5）:2442-57

标准品 渥曼青霉素/沃氏篮素/Wortmannin/WT

产品信息

标准品渥曼青霉素/沃氏篮素/Wortmannin/WT