04-0010 Stemolecule™ SB431542 （5 mg）

 Stemolecule™ SB431542是TGF-β1活化受体激酶的YZ剂。是ALK-4, -5 ，-7的潜在YZ剂，SB431542YZ内在的活化剂以及TGF-β信号，而不影响应用ALK-1, -2, -3,  -6的BMP信号。据报道，1μM浓度的SB431542能刺激来源于胚胎干细胞的内胚层细胞的增殖，分化和形成

Stemolecule™ SB431542 is an inhibitor of the TGF-β1 activin receptor-like kinases (ALKs). It is a selective and potent inhibitor of ALK-4, -5 and -7. SB431542 inhibits endogenous activin and TGF-β signaling without affecting more divergent BMP signaling utilizing ALK-1, -2, -3, and -6^{1, 2}. Watabe and colleagues (2003) reported that at a concentration of 1μM, SB431542 stimulates proliferation, differentiation, and sheet formation of endothelial cells derived from embryonic stem cells³.

Chemical Formula	C22H16N4O3
Alternate Name	4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin- 2-yl-1H-imidazol-2-yl)-benzamide hydrate 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H- imidazol-2-yl]-benzamide hydrate 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)- 1H-imidazol-2-yl]-benzamide hydrate
Structure
Molecular Weight	384.4
CAS Number	301836-41-9 (anhydrous)
PubChem Substance ID	24724609
Purity	>98.3% by HPLC analysis
Formulation	White solid
Solubility	Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 1301 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
Storage	4°C protected from light. Following reconstitution, store aliquots at -20°C
Stability	Stock solutions stable at -20°C for 6 months
Quality Control	The purity of SB431542 was determined by HPLC analysis. The accurate mass and structure of SB431542 was determined by mass spectrometry and NMR, respectively. Cellular toxicity of PD173074 was tested by using HeLa and HEK293 cells.

产品货号及价格

Y-27632

CHIR99021

PD0325901

A83-01 

SB 431542