04-0006 Stemolecule™ PD0325901（2 mg）

PD0325901是具有生物效应的小分子，作用于MEK，具有潜在的抗肿瘤药性。PD0325901是MEKYZ剂CI-1040的衍生物，选择性的与之结合并YZMEK，YZMAPK/ERK的激活和磷酸化，并且YZ肿瘤细胞的增殖。

PD0325901 is an orally bioavailable, synthetic organic molecule targeting mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. PD0325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation^1,2.

Chemical Formula	C16H14F3IN2O4
Structure
Molecular Weight	482.19
Purity	>98% by HPLC analysis
Formulation	Pale purple solid
Solubility	Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 415 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
Storage	4°C protected from light. Following reconstitution, store aliquots at -20°C
Stability	Stock solutions stable at -20°C for 6 months
Quality Control	The purity of PD0325901 was determined by HPLC analysis. The accurate mass and structure of PD0325901 was determined by mass spectrometry and NMR, respectively. Cellular toxicity of PD0325901 was tested by using HeLa and HEK293 cells.

产品价格及规格

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SB 431542