CAL-101, as a PI3K-delta selective inhibitor, can potently inhibit p110delta with IC50 of 2.5 nM and EC50 of 8nM. CAL-101 blocked constitutive phosphatidylinositol-3-kinase signaling as constitutive phosphatidylinositol-3-kinase pathway activation is p110delta-dependent.
CAL-101, as a PI3K-delta selective inhibitor, can potently inhibit p110delta with IC50 of 2.5 nM and EC50 of 8nM. CAL-101 blocked constitutive phosphatidylinositol-3-kinase signaling as constitutive phosphatidylinositol-3-kinase pathway activation is p110delta-dependent.