572924-54-0 Deforolimus （Ridaforolimus）

Cat No.

CEI-0129

Description

Deforolimus (Ridaforolimus, AP23573, MK-8669) can inhibit mTOR with IC50 of 0.2 nM.

Alias

AP23573, MK-8669

CAS No.

572924-54-0

Molecular Weight

990.21

Purity

>99%

Storage

2 years at -20centigrade Powder

Synonyms

AP23573, MK-8669

Targets

mTOR

Molecular Formula

C53H84NO14P

Solubility

DMSO 198 mg/mL Water

In vitro

Deforolimus can inhibit phosphorylation of S6 and 4E-BP1 with IC50 of 0.2 nM and 5.6 nM in HT-1080 cells in a dose-dependent manner. Deforolimus can also induce cell cycle arrest in G1 phase and inhibit glucose uptakeing, resulting in decreaseing the size of cells.