P038 Polymyxin B1-I sulfate, EvoPure/硫酸多粘菌素B1-I, EvoPure

Polymyxin B1-I sulfate, EvoPure/硫酸多粘菌素B1-I, EvoPure
产品编号：P038 
产品规格：10mg

Molecular Formula	C56H98N16O13*H2O4S
Molecular Weight	1301.57 g/mol
Appearance	White powder
Purity Level	≥99.0%
Solubility	Water: Soluble
Source	Pseudomonas Sp.
Storage Conditions	2-8 °C

Description
Polymyxin B1-I sulfate is one of the individual polypeptide components in polymyxin B sulfate. Polymyxin B1-I contains, among other amino acids, an L-isoleucine residue in place of the L-leucine reside found in the other polymyxin fractions. The unique fatty acid group found in B1-I is 6-methyloctanoic acid (6-MOA), the same group found in polymyxin B1.
TOKU-E offers five forms of polymyxin B sulfate: polymyxin B sulfate (P007), polymyxin B1 sulfate, EvoPure? (P037), polymyxin B1-I sulfate, EvoPure? (P038), polymyxin B2 sulfate, EvoPure? (P039), and polymyxin B3 sulfate, EvoPure? (P040). EvoPure? products are purified single antibiotic fractions, most >99% pure. High purity EvoPure? polymyxin products can be used to analyze the specifc effects of individual polymyxin B sulfate fractions.
Mechanism
Polymyxin B targets and alters permeability lipopolysaccharide (LPS) of gram negative bacteria leading to lysing of the cell. Polymyxin B only needs to interact with LPS, it is not required to enter the cell.
Spectrum
Polymyxin B sulfate targets the outer membrane of gram negative bacteria especially Pseudomonas aeruginosa.
Microbiology Applications
Polymyxin B sulfate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:Pseudomonas aeruginosa 0.25 μg/mL – 1 μg/mL
For a complete list of polymyxin B sulfate MIC values, click here.Plant Biology Applications