Asc-215 ω-Conotoxin GVIA

Biological Description

Synthetic toxin originally isolated from Conus geographus. Specific blocker of Cav2.2 (N-type) Ca²⁺ channels. Binds to the Cav2.2α1 subunit (α1B) and its action is only partially reversible.

Useful References

Feng et al (2001) Residue Gly1326 of the N-type calcium channel alpha 1B subunit controls reversibility of omega-conotoxin GVIA and MVIIA block. J Biol Chem. 276:15728-35 abstract



Terlau et al (2004) Conus venoms: a rich source of novel ion channel-targeted peptides. Physiol Rev. 84:41-68 abstract



Olivera et al (1994) Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins. Annu Rev Biochem. 63:823-67. abstract

 

Chemical Information

CKS-Hyp-GSSCS-Hyp-TSYNCCRSCN-Hyp-YTKRCY-NH2 disulfide bridges: 1 - 16, 8 - 19, 15 - 26

• Desiccate at -20°C


• MW 3037.4


• Soluble in water


• C₁₂₀H₁₈₂N₃₈O₄₃S₆


• 106375-28-4