Biological Description
Synthetic toxin originally isolated from Conus geographus. Specific blocker of Cav2.2 (N-type) Ca2+ channels. Binds to the Cav2.2α1 subunit (α1B) and its action is only partially reversible. |
Useful References
Feng et al (2001) Residue Gly1326 of the N-type calcium channel alpha 1B subunit controls reversibility of omega-conotoxin GVIA and MVIIA block. J Biol Chem. 276:15728-35 abstract
Terlau et al (2004) Conus venoms: a rich source of novel ion channel-targeted peptides. Physiol Rev. 84:41-68 abstract
Olivera et al (1994) Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins. Annu Rev Biochem. 63:823-67. abstract
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Chemical Information
CKS-Hyp-GSSCS-Hyp-TSYNCCRSCN-Hyp-YTKRCY-NH2 disulfide bridges: 1 - 16, 8 - 19, 15 - 26 |
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- Desiccate at -20°C
- MW 3037.4
- Soluble in water
- C120H182N38O43S6
- 106375-28-4
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