BIA-P1275 Pravastatin sodium/普伐他汀钠

Pravastatin sodium/普伐他汀钠
产品编号：BIA-P1275 
产品规格：25 mg/100 mg
Synonyms : Mevalotin, CS 514, SQ 31000
Specifications
CAS # : 81131-70-6
Molecular Formula : C23H35O7 Na
Molecular Weight : 446.5
Source : Absidia sp.
Appearance : White powder
Purity : > 98% by HPLC
Storage : -20°C
Solubility : Soluble in water, methanol and DMSO.
Application Notes
Pravastatin sodium is the sodium salt of pravastatin, a ring-opened member of the statin family. Pravastatin
is produced biosynthetically from compactin (ML-236B) by a number of micro-organisms, notably Absidia,
Cunninghamella, Syncephalastrum, Nocardia or Streptomyces. Typically, statins like compactin, lovastatin
and simvastatin possess a β-hydroxy lactone ring which is a pro-drug for the readily ring-opened
dihydroxyacid generally regarded as the active HMG-CoA inhibitor. Importantly, the free carboxylic acid
enables pravastatin to be freely water soluble within biological pH ranges. Pravastatin is used therapeutically
to reduce LDL cholesterol.
References
1. Terahara A. US Patent 4,346,227 (1982).
2. Terahara A. US Patent 4,537,859 (1985).
3. Effect of CS-514, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on lipoprotein and
apolipoprotein in plasma of hypercholesterolemic diabetics. Yoshino G. et al. Diabetes Res. Clin. Pract.1986, 2, 179.
4. CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective
inhibition of sterol synthesis and hypolipidemic effect on various animal species. Tsujita Y. et al.
Biochim Biophys Acta 1986, 877, 50.
Pravastatin sodium/普伐他汀钠
货号： BIA-P1275 包装规格: 25 mg, 100 mg
同义词：美百乐镇, CS 514, SQ 31000
CAS号: 81131-70-6
分子式: C23H35O7 Na
分子量: 446.5
来源: 来自于犁头霉属
纯度: > 98% by HPLC