Indomethacin heptyl ester

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产品名称：Indomethacin heptyl ester

产品别名：Heptyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acet ate

CAS号：282728-47-6

英文别名：Heptyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acet ate

分子量：456

分子式：C₂₆H₃₀ClNO₄

纯度：≥98%

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保存方法：Store at -20℃

描述：Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2 in sheep and humans.¹ Structurally, indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivatized as an ester or amide. These derivatives show enhanced selectivity for the COX-2 isoform. For example, the IC₅₀ for indomethacin heptyl ester for the inhibition of human recombinant COX-2 is 0.04 µM, making it more than 1,700 times more potent as an inhibitor of COX-2 than COX-1.² While indomethacin itself has an IC₅₀ of 0.05 µM for the inhibition of COX-2, it also inhibits COX-1 with a corresponding IC₅₀ of 0.67 µM.²

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