(R)-nitro-Blebbistatin

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产品名称：(R)-nitro-Blebbistatin

产品别名：R-(−)-7-Desmethyl-8-nitro Blebbistatin;

CAS号：1217619-62-9

英文别名：(R)-nitro-Blebbistatin

分子量：323.3

分子式：C₁₇H₁₃N₃O₄

纯度：≥98%

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保存方法：Store at -20℃

描述：(−)-Blebbistatin (Item No. 13013) is a selective, cell-permeable inhibitor of non-muscle myosin II ATPases that blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells.^1,2 However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications.^3,4 To circumvent this issue, a nitro group analog of (−)-blebbistatin, (S)-nitro-blebbistatin (Item No. 13891) was developed to improve stability under prolonged irradiation at 450-490 nm.⁵ (R)-nitro-Blebbistatin is a nitro group-containing blebbistatin analog with the same stereochemistry as the inactive (+)-blebbistatin (Item No. 13165) enantiomer.

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