Prostaglandin E2 Ethanolamide,N-(2-hydroxyethyl)-7-[(2R)-3-hydroxy-2-(3-hydroxyoct-1-enyl)-5-oxocyclopentyl]hept-5-enamide,194935-38-1

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产品名称：Prostaglandin E2 Ethanolamide

产品别名：N-(2-hydroxyethyl)-7-[(2R)-3-hydroxy-2-(3-hydroxyoct-1-enyl)-5-oxocyclopentyl]hept-5-enamide

CAS号：194935-38-1

英文别名：N-(2-hydroxyethyl)-7-[(2R)-3-hydroxy-2-(3-hydroxyoct-1-enyl)-5-oxocyclopentyl]hept-5-enamide

分子量：395.5

分子式：C₂₂H₃₇NO₅

纯度：见爱必信官网

外观：见爱必信官网

保存方法：Store at -20° C

描述：Prostaglandin E2 Ethanolamide is an analog of PGE2 with improved water solubility and stability that has demonstrated the ability to induce apoptosis in HT29 and HCA7/C29 human colorectal carcinoma (CRC) cell lines. Shown to act as an agonist with all four known EP receptor subtypes (EP1 - EP4), but with an affinity that is significantly less than PGE2. This compound is thought to be biosyntesized via COX-2 from the precursor anandamide (; N-arachidonoylethanolamide), the endogenous cannabinoid neurotransmitter. These prostaglandin analogues are integral for structure-activity studies used in the deconvolution of these complex biochemical pathways, and in this case demonstrates unique and applicable biochemical activity.

应用：An analog of PGE2 shown to bind EP1,2,3, &4 receptors and induce apoptosis in CRC cells

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