Methotrexate-methyl-d3, Dimethyl Ester,Methotrexate-methyl-d3, Dimethyl Ester,432545-60-3

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产品名称：Methotrexate-methyl-d3, Dimethyl Ester

产品别名：N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic Acid-d3 Dimethyl Ester

CAS号：432545-60-3

英文别名：N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic Acid-d3 Dimethyl Ester

分子量：485.51

分子式：C₂₂H₂₃D₃N₈O₅

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保存方法：Store at -20° C

描述：Methotrexate-methyl-d3 is a deuterated esterified form of Methotrexate which is an antineoplastic and antirheumatic agent. Studies indicate that Methotrexate-methyl-d3 can act as a folic acid antagonist. Methotrexate competitively and irreversibly inhibits DHFR (dihydrofolate reductase) which is essential in tetrahydrofolate synthesis. In addition, the reduction in tetrahydrofolate synthesis causes a decrease in purine base synthesis which results in the inhibition of DNA, RNA, thymidylates, and proteins. Alternate studies suggest that Methotrexate-methyl-d3 can suppress T cell activation and adhesion molecule expression through IL-1 suppression..

应用：A deuterated esterified folic acid antagonist

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