FTY720 (R)-Phosphate,[2-amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl] dihydrogen phosphate,402616-23-3

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产品名称：FTY720 (R)-Phosphate

产品别名：[2-amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl] dihydrogen phosphate

CAS号：402616-23-3

英文别名：[2-amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl] dihydrogen phosphate

分子量：387.5

分子式：C₁₉H₃₄NO₅P

纯度：≥98%

外观：见爱必信官网

保存方法：Store at -20° C

描述：FTY720 (R)-Phosphate, FTY720 is a novel immune modulator that inhibits lymphocyte emigration from lymphoid organs, which prolongs allograft transplant survival in numerous models. Sphingosine kinases phosphorylate FTYS20 in vivo so that FTYS20 acts as a potent agonist at four of the five sphingosine-1-phosphate (S1P) receptors . FTY720 (R)-phosphate is one stereoisomer of FTY720-phosphate, but it is evidently not formed in vivo. FTY720 (S)-phosphate exhibits K_i values of 2.1, 5.9, 23, and 2.2 nM for S1P1,3,4,5, respectively, while the R isomer binds with 5-130-fold lower affinity.

应用：An immunomodulator & inhibitor of lymphocyte emigration as well as a S1P agonist

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