Tyrphostin A25,酪氨酸磷酸化YZ剂25,118409-58-8

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试剂描述：

产品名称：Tyrphostin A25

产品别名：Tyrphostin 25; RG-50875; NSC 676484; Tyrphostin AG-82

CAS号：118409-58-8

英文别名：Tyrphostin 25; RG-50875; NSC 676484; Tyrphostin AG-82

分子量：202.16

分子式：C₁₀H₆N₂O₃

纯度：≥95%

外观：见爱必信官网

保存方法：Store at -20° C

描述：Tyrphostin A25 is a cell-permeable, competitive and reversible inhibitor of substrate binding on protein tyrosine kinases. In cultured rat hepatocytes, Tyrphostin A25 has been shown to inhibit endocytosis of tyramine-cellobiose-asialoorosomucoid (TC-AOM). It has also shown to inhibit neuromedin B-induced phosphorylation of focal adhesion kinase (p125FAK). Inhibits EGFR (epidermal growth factor receptor) tyrosine kinase (IC₅₀=3 µM ) and the GTPase activity of transducin. In small cell lung cancer cells tyrphostin A25 has been observed to obstruct neuropeptide and basal stimulated growth. In addition it has blocked the induction of inducible NO synthase in glial cells and in human leukemic cell lines has induced apoptosis.

应用：A cell-permeable, reversible, and competitive protein tyrosine kinase (PTK) substrate inhibitor

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