FR 122047 hydrochloride hydrate,1-[[4,5-双(4-基)-2-噻唑]羰基]-4-甲基哌嗪盐酸盐,130717-51-0

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产品名称：FR 122047 hydrochloride hydrate

产品别名：1-[[4,5-双(4-基)-2-噻唑]羰基]-4-甲基哌嗪盐酸盐

CAS号：130717-51-0

英文别名：FR 122047 hydrochloride,1-[[4,5-bis(4-Methoxyphenyl)-2-thiazolyl]carbonyl]-4-methylpiperazinehydrochloride

分子量：459.99

分子式：C₂₃H₂₅N₃O₃S•HCl

纯度：见爱必信官网

外观：见爱必信官网

保存方法：Store at -20° C

描述：FR 122047 hydrochloride is the hydrochloride salt preparation of FR 122047 and is a Cox-1 (cyclooxygenase-1) and Cox-2 inhibitor. FR 122047 is highly selective for Cox-1 (IC₅₀ of 0.028 μM) over Cox-2 (IC₅₀ of 65 μM). This compound has been shown to inhibit arachidonic acid -induced guinea-pig platelet aggregation in vitro. FR 122047 also displays the capacity to inhibit malondialdehyde (MDA) synthesis and cause vasodilation in vitro. Further studies suggest that FR 122047 is also capable of suppressing prostaglandin E2 (PGE2, ) and Thromboxane B2 (TXB2, ) levels which results in an anti-inflammatory effect.

应用：A highly selective Cox-1 inhibitor

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