AG 538,TYRPHOSTIN AG 538,133550-18-2

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试剂描述：

产品名称：AG 538

产品别名：α-Cyano-(3,4-dihydroxy)cinnamoyl-(3′,4′-dihydroxyphenyl)ketone

CAS号：133550-18-2

英文别名：α-Cyano-(3,4-dihydroxy)cinnamoyl-(3′,4′-dihydroxyphenyl)ketone

分子量：297.3

分子式：C₁₆H₁NO₅

纯度：≥95%

外观：见爱必信官网

保存方法：Store at -20° C

描述：AG 538 is a potent, competitive inhibitor of IGF-IR (IGF-1 receptor kinase, IC₅₀ = 400 nM). Reaction is competitive with respect to IGF-1R substrate. Also inhibits the phosphorylation of PTK substrate poly(Glu,Tyr) by IGF-1R, IR, EGF-R, and Src (IC₅₀ = 60 nM, 113 nM, 370 nM, and 2.4 μM, respectively). Inhibits the phosphorylation of PKB at a much higher concentration (IC₅₀ = 76 μM).

应用：A potent, competitive inhibitor of IGF-1 receptor kinase

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