Thrombin Receptor Peptide Ligand (trifluoroacetate salt)

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产品名称：Thrombin Receptor Peptide Ligand (trifluoroacetate salt)

产品别名：L-alanyl-L-phenylalanyl-L-leucyl-L-alanyl-L-arginyl-L-alanyl-L-alanine, trifluoroacetate salt

英文别名：L-alanyl-L-phenylalanyl-L-leucyl-L-alanyl-L-arginyl-L-alanyl-L-alanine;trifluoroacetate salt

靶点：Others

CAS：见爱必信官网

纯度：≥95%

外观：A lyophilized powder

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Thrombin receptor peptide ligand is antagonist of the thrombin receptor (EC50s = 16-33 µM to inhibit platelet aggregation in vitro). It inhibits α-thrombin and platelet aggregation induced by thrombin receptor activating peptide  in vitro when used at a concentration of 32 µM but does not affect platelet aggregation induced by ADP or collagen. It also inhibits thrombin- and TRAP-induced proliferation of vascular smooth muscle cells (VSMCs). Thrombin receptor peptide ligand (100 µmol/kg bolus, i.v., plus 900 µmol/kg infusion) inhibits arterial thrombosis in a rabbit model of partial carotid artery occlusion without increasing bleeding time.

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体外研究：

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