MCB-613,1162656-22-5

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产品名称：MCB-613

产品别名：见爱必信官网

英文别名：MCB-613

靶点：SRC

CAS：1162656-22-5

纯度：见爱必信官网

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：MCB-613 is a potent steroid receptor coactivator (<b>SRC</b>) stimulator.

溶解性：体外:
DMSO 60mg/mLwarming(197.11mM)
Ethanol 60mg/mLwarming(197.11mM)
Water <1mg/mL

4%DMSO+30%PEG300+ddH2O 2mg/mL

体外研究：

MCB-613 selectively and reversibly binds to the RID of SRC-3, and selectively kills cancer cells including MCF-7 (breast), PC-3 (prostate), H1299 (lung), and HepG2 (liver) cells, without toxicity to mouse primary hepatocytes and mouse embryonic fibroblasts (MEFs). MCB-613 also increases SRCs’ interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS).

体内研究：In an MCF-7 breast cancer mouse xenograft model, MCB-613 (20 mg/kg, i.p.) significantly and dramatically inhibits the growth of the tumor while causing no obvious animal toxicity and body weight less.

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