Cyclo (-RGDfK) TFA,161552-03-0(freebase)

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YZ剂描述：

产品名称：Cyclo (-RGDfK) TFA

产品别名：Cyclo (-RGDfK)

英文别名：Cyclo (-RGDfK) TFA

靶点：αvβ3 integrin

CAS：161552-03-0(freebase)

纯度：≥98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Cyclo (-RGDfK) is a potent and selective <b>αvβ3 integrin</b> inhibitor.

溶解性：Water ：100 mg/mL (139.34 mM)

体外研究：

The constant of affinity (KD) of Cyclo (-RGDfK-) for purified integrin is 41.70 nM. Cyclo (-RGDfK) is reacting with HEK293(β3) cells moderately. Cyclo(-RGDfK-) modified micelles shows strong affinity to T-24 cells and strong inhibitory effect on the proliferation of T-24 cells.

体内研究：In athymic mice bearing α(v)β(3)-integrin-positive C6 gliomas, Cyclo (-RGDfK-) modification induces less tumor progression, less tumor metabolic activity, fewer intratumoral vessels.

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