Mouse Flt3/Receptor-type tyrosine-protein kinase FLT3 ELISA Kit

产品类型：
ELISA kit
研究领域：

产品概述：
EK00496E is a ready-to-use microwell,strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A Disintegrin and Metalloprotease 30 (Receptor-type tyrosine-protein kinase FLT3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Receptor-type tyrosine-protein kinase FLT3 The ELISA analytical biochemical technique of the EK00496E kit is based on Receptor-type tyrosine-protein kinase FLT3 antibody-Receptor-type tyrosine-protein kinase FLT3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Receptor-type tyrosine-protein kinase FLT3 antigen targets in samples. The ELISA Kit is designed to detect native, recombinant, Receptor-type tyrosine-protein kinase FLT3
细胞定位：
Membrane Single-pass type I membrane protein Endoplasmic reticulum lumen Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation (By similarity).
分析类型：
Sandwich
检测方法：
spectrophotometrical
反应性：
Mouse
检测范围："

31.2-2000pg/mL
试剂盒组分：
Assay Plate, Standard, Sample Diluent, Assay Diluent A&B, Detection Reagent A&B, Wash Buffer, Substrate, Stop Solution.
基因名称：
Flt3
功能：
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
应用：
For research use only
联系方式：

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