C5a Anaphylatoxin Receptor (extracellular) Antibody

分子量：
39336 Da
细胞定位：

形式：
Affinity purified antibody, Liquid
参考文献：
1. Haas, P.J. and van Srijp, J. (2007) Immun. Res. 37, 161.2. Marder, S.R. et al. (1985) J. Immunol. 134, 3325.3. Guo, R.F. and Ward, P.A. (2005) Annu. Rev. Immunol. 23, 821.4. Schumacher, W.A. et al. (1991) Agents Actions 34, 345.5. Laudes, I.J. et al. (2002) Am. J. Pathol. 160, 1867.6. Geva, A. et al. (2000) J. Biol. Chem. 275, 35393.7. Klco, J.M. et al. (2003) J. Biol. Chem. 278, 35345.8. Monk, P.N. et al. (2007) Br. J. Pharmacol. 152, 429.9. Huttenrauch, F. et al. (2005) J. Biol. Chem. 280, 37503.10. Ward, P.A. (2009) J. Mol. Med. 87, 375.11. Gerard, N.P. et al. (1989) J. Biol. Chem. 264, 1760.12. Werfel, T. et al. (1992) Blood 79, 152.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality C5a Anaphylatoxin Receptor (extracellular) antibody.
功能：

总结：
The innate immune system identifies pathogens by recognizing known elements. This response ultimately leads to the production of proinflammatory substances and the activation of phagocytic neutrophils and macrophages1. Activation of the complement system is an important initial even in the response against pathogens. This system includes some thirty different proteins that act together to form a complex1. C5a is one of the most potent inflammatory peptides generated by complement activation. This peptide has many functions such as acting as a chemoattractant for neutrophils2,3. C5a acts as a vasodilator3,4 and activates the coagulation pathway3,5 just to name a few. C5a exerts its numerous actions by binding to C5aR and C5L2. C5aR belongs to the superfamily of G-protein coupled receptors (GPCRs). Like all members, C5aR has seven transmembrane domains, an extracellular N-terminus and an intracellular C-terminal tail. C5aR can form homodimers6-8 or heteromer with CCR5, chemokine receptor, for example8,9. Activation of C5aR by C5a binding causes Ca2+ mobilization10. C5aR expression is detected in neutrophils, eisinophils, basophils and monocytes3,11,12. The receptor is also expressed in lung and liver13,14. Blocking C5aR by peptides or organic small molecules is in the pipeline for treating chronic inflammatory disorders/diseases like arthritis, inflammatory bowel disease and lung/liver injuries8. Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of human C5aR. Anti-C5a Anaphylatoxin Receptor (extracellular) antibody (#AG1372) can be used in western blot and indirect flow cytometry applications. It has been designed to recognize C5aR from human samples.
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