Melanocortin Receptor 1 Antibody

分子量：
34706 Da
细胞定位：

形式：
Affinity purified antibody, Liquid
参考文献：
References1. Abdel-Malek, Z.A. (2001) Cell. Mol. Life Sci. 58, 434.2. Gantz, I. and Fong, T.M. (2003) Am. J. Physiol.284, E468.3. Wikberg, J.E.et al. (2000) Pharm. Res.42, 393.4. Dinulescu, D.M. and Cone, R.D. (2000) J. Biol. Chem. 275, 6695.5. Kanetsky, P.A. et al. (2006) Cancer Res. 66, 9330.6. Catania, A. et al. (2004) Pharmacol. Rev. 56, 1.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality Melanocortin Receptor 1 antibody.
功能：

总结：
Melanocortin Receptor 1 (MC1R) belongs to a five-member receptor family known as the melanocortin receptors. The melanocortin receptors are members of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.The receptors ligands, the melanocortins, are a group of structurally derived peptides consisting of α-, β- and γ-melanocyte stimulating hormone (α, β, γ-MSH) and the adrenocorticotropic hormone (ACTH) all of which are derived from the post-translational processing of a common precursor peptide, proopiomelanocortin (POMC).1,2,3One of the most salient features of the melanocortin signaling system is the presence of two endogenous antagonists, that is proteins that bind specifically to the receptor but instead of activating it have an inhibitory effect. The antagonist proteins are termed agouti (or agouti signaling protein, ASP) and agouti-related protein (AGRP).4All five melanocortin receptors bind their agonists (the melanocortins) and their endogenous antagonists (agouti and AGRP) with different affinities.MC1R was the first member of the melanocortin receptor family to be cloned. The receptor transduces signals via Gsresulting in the activation of adenylate cyclase and production of cAMP.MC1R binds its ligands with the following potency: α-MSH = ACTH > β-MSH > γ-MSH. MC1R also binds the endogenous antagonist agouti with high affinity.1, 2MC1R can be described as the “classical” melanocyte α-MSH receptor. The receptor is expressed in the skin where it has a key role in determining skin and hair pigmentation. In fur-bearing mammals, the local ratio between α-MSH and agouti will determine coat pigmentation as α-MSH stimulates and agouti inhibits melanin production.In humans, especially in Caucasians, the MC1R gene is highly polymorphic and several allelic variants have been correlated with red-hair, poor tanning ability and increased risk of melanoma.1,3,5In addition, MC1R expression in melanoma has been shown to be upregulated up to 20-fold when compared to normal melanocytes.The melanocortins and particularly α-MSH have significant anti-inflammatory properties. Since α-MSH binds to MC1R with the highest potency, it was proposed that the latter mediated the anti-inflammatory effects of α-MSH. Indeed, MC1R expression has been demonstrated in several cells of the immune system including macrophages and neutrophils.6
联系方式：

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

地 址：北京经济技术开发区永昌中路4号院4号楼3层