KV2.1 Antibody

分子量：
95637 Da
细胞定位：

形式：
Affinity purified antibody, Liquid
参考文献：
References1. Albrecht, B. et al. (1993) Receptors Channels 1, 99.2. Murakoshi, H. and Trimmer, J.S. (1999) J. Neurosci. 19, 1728.3. Archer, S.L.et al. (1998) J. Clin. Invest. 101, 2319.4. Escoubas, P. et al. (2002) Mol. Pharmacol. 62, 48.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality KV2.1 antibody.
功能：

总结：
KV2.1 is a member of the voltage-gated K+channel superfamily. Together with the closely related KV2.2 protein they form the KV2 subfamily also known asShab.1As with all KVchannels, KV2.1 possesses the signature structure of the voltage-dependent K+channels: six membrane-spanning domains with intracellular N and C termini. The functional KVchannel is a tetramer that can either be a homotetramer or a heteromer of KV2.1 and KV2.2 subunits.Both KV2.1 and KV2.2 channels are known as delayed rectifiers that is, channels that are activated by changes in membrane potential (depolarization) but inactivate very slowly. The current they form is known as IKor IDR. Accessory subunits such as KChaP and the electrically silent a subunits KV8 and KV9 can modulate biochemical and biophysical properties of KV2.1.2KV2.1 is widely expressed throughout the body including brain, lung, pancreas, skeletal muscle and pulmonary artery.2The main function of KV2.1 is to maintain membrane potential and to modulate the electrical excitability in neurons and muscle. In rat pulmonary artery it probably mediates hypoxic pulmonary vasoconstriction together with the KV9.3 subunit.3Several toxins from spider venomsare potent blockers (affecting the channels in the nanomolar range) of KV2.1channels. Among these the most potent and selective areStromatoxin-1(#STS-350), (12.7 nM)4 andHanatoxin (42 nM).4
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