A2B Adenosine Receptor (extracellular) Antibody

分子量：
36333 Da
细胞定位：

形式：
Affinity purified antibody, Liquid
参考文献：
1. Okusa, M.D. (2002) Am. J. Physiol. Renal Physiol. 282, F10.2. Fredholm, B.B. et al. (2001) Pharmacol. Rev. 53, 527.3. Nakata, H. (1989) J. Biol. Chem. 264, 16545.4. Baraldi, P.G. et al. (2006) Curr. Med. Chem. 13, 3467.5. Polosa, R. (2002) Eur. Respir. J. 20, 488.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality A2B Adenosine Receptor (extracellular) antibody.
功能：

总结：
Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including brain and heart.1,2 Adenosine exerts its action via four specific adenosine receptors (also named P1 purinergic receptors):A1-Adenosine Receptor (A1AR), A2A-Adenosine Receptor (A2AAR), A2B-Adenosine Receptor (A2BAR), and A3-Adenosine Receptor (A3AR). All are integral membrane proteins and members of the G Protein-Coupled Receptor superfamily. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, a cytoplasmic carboxyl terminus, and a third intracellular loop that is important in binding G proteins.1-3 The various adenosine receptors can be distinguished on the basis of their distinct molecular structures, distinct tissue distributions, and differential selectivity for adenosine analogs.1-4 The A2 Adenosine receptor subtype was subdivided according to affinity for adenosine; A2AAR has high affinity and A2BAR has low affinity. A2BAR is expressed in mast cells, neutrophils, monocytes, macrophages, dendritic cells, T cells, bronchial epithelium, intestinal epithelium, smooth muscle, brain, and other cells.5 In intestinal epithelia, A2BAR was found to be the major adenosine receptor subtype expressed and is thought to be involved in diarrheal diseases. It is also believed to be involved in the pathogenesis of chronic airway inflammatory diseases.4 Thus, antagonists of A2BAR might be effective for the treatment of inflammatory gastrointestinal tract disorders4 as well as asthma and chronic obstructive pulmonary disease.5 Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of the human A2B Adenosine receptor (A2BAR). The Anti-A2B-Adenosine Receptor (extracellular) antibody (#AG1385) can be used for western blot immunohistochemical applications. It has been designed to recognize A2B-Adenosine receptor from human, rat and mouse samples.
联系方式：

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

地 址：北京经济技术开发区永昌中路4号院4号楼3层