CREBBP / CREB Binding Protein Antibody (aa2422-2441)

分子量：
265kDa
细胞定位：
Antigen Cellular Localization:Cytoplasm. Nucleus. Note=Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus
形式：
Liquid. In PBS containing 0.02% sodium azide.
参考文献：
Sobulo O.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:8732-8737(1997).Giles R.H.,et al.Genomics 42:96-114(1997).Petrij F.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.Nakajima D.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality CREBBP / CREB Binding Protein antibody (aa2422-2441).
功能：
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2- ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.
总结：
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2- ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.
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