MAdCAM-1 Antibody (clone 314G8, Low Endotoxin)

分子量：
40kDa
细胞定位：
Antigen Cellular Localization:Membrane; Single-pass type I membrane protein
形式：
Liquid
参考文献：
Leung E.,et al.Immunol. Cell Biol. 74:490-496(1996).Shyjan A.M.,et al.J. Immunol. 156:2851-2857(1996).Leung E.,et al.Immunogenetics 46:111-119(1997).Wang P.Z.,et al.Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.Grimwood J.,et al.Nature 428:529-535(2004).
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality MAdCAM-1 antibody (clone 314G8, Low Endotoxin).
功能：
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L- selectin binding.
总结：
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L- selectin binding.
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