ESRRA / ERR Alpha Antibody (Ligand-binding Domain)

分子量：
46kDa
细胞定位：
Antigen Cellular Localization:Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:18063693}
形式：
Liquid
参考文献：
Giguere V.,et al.Nature 331:91-94(1988).Yang N.,et al.J. Biol. Chem. 271:5795-5804(1996).Taylor T.D.,et al.Nature 440:497-500(2006).Wiley S.R.,et al.Genes Dev. 7:2206-2219(1993).Sladek R.,et al.Mol. Cell. Biol. 17:5400-5409(1997).
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality ESRRA / ERR Alpha antibody (Ligand-binding Domain).
功能：
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
总结：
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
联系方式：

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

地 址：北京经济技术开发区永昌中路4号院4号楼3层