IGF2BP2 Antibody (C-term)

分子量：
H=66,62,55,59;M=66,59 KDa
细胞定位：
Antigen Cellular Localization:Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules
形式：
Liquid. In PBS containing 0.02% sodium azide.
参考文献：
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Pechlivanis, S., et al. Arterioscler. Thromb. Vasc. Biol. 30(9):1867-1872(2010)Heni, M., et al. Diabetes (2010) In press :Rodriguez, S., et al. Growth Horm. IGF Res. 20(4):310-318(2010)Voight, B.F., et al. Nat. Genet. 42(7):579-589(2010)
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality IGF2BP2 antibody (C-term).
功能：
RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta- actin/ACTB and MYC transcripts.
总结：
This gene encodes a member of the IGF-II mRNA-bindingprotein (IMP) family. The protein encoded by this gene containsseveral four KH domains and two RRM domains. It functions bybinding to the 5' UTR of the insulin-like growth factor 2 (IGF2)mRNA and regulating IGF2 translation. Alternate transcriptionalsplice variants, encoding different isoforms, have beencharacterized.
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