Goat Anti-14-3-3 sigma / Stratifin Antibody

分子量：
27774 Da
细胞定位：
Antigen Cellular Localization:Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway
形式：
0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
参考文献：
Hypermethylated 14-3-3-sigma and ESR1 gene promoters in serum as candidate biomarkers for the diagnosis and treatment efficacy of breast cancer metastasis. Zurita M, et al. BMC Cancer, 2010 May 20. PMID 20487521.The expression of seven 14-3-3 isoforms in human meningioma. Liu Y, et al. Brain Res, 2010 Jun 8. PMID 20388496.[Expression and clinical significance of 14-3-3 sigma and heat shock protein 27 in colorectal cancer] Pei HP, et al. Zhonghua Wei Chang Wai Ke Za Zhi, 2010 Mar. PMID 20336542.Reduced stratifin expression can serve as an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma. Ren HZ, et al. Dig Dis Sci, 2010 Sep. PMID 20108042.Up-regulation of 14-3-3sigma (Stratifin) is associated with high-grade CIN and high-risk human papillomavirus (HPV) at baseline but does not predict outcomes of HR-HPV infections or incident CIN in the LAMS study. Syrj脌nen S, et al. Am J Clin Pathol, 2010 Feb. PMID 20093232.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality Goat Anti-14-3-3 sigma / Stratifin antibody.
功能：
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
总结：

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