PLOD1 Antibody (N-term)

分子量：
83550 Da
细胞定位：
Antigen Cellular Localization:Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side
形式：
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献：
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :Huang, Q.Y., et al. Bone 44(5):984-988(2009)Yamada, Y., et al. Int. J. Mol. Med. 19(5):791-801(2007)Tasker, P.N., et al. Osteoporos Int 17(7):1078-1085(2006)Giunta, C., et al. Mol. Genet. Metab. 86 (1-2), 269-276 (2005) :
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality PLOD1 antibody (N-term).
功能：
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
总结：
Lysyl hydroxylase is a membrane-bound homodimeric proteinlocalized to the cisternae of the endoplasmic reticulum. The enzyme(cofactors iron and ascorbate) catalyzes the hydroxylation of lysylresidues in collagen-like peptides. The resultant hydroxylysylgroups are attachment sites for carbohydrates in collagen and thusare critical for the stability of intermolecular crosslinks. Somepatients with Ehlers-Danlos syndrome type VI have deficiencies inlysyl hydroxylase activity.
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