Cytokeratin 10 (KRT10) (Suprabasal Epithelial Marker) Antibody - With BSA and Azide

分子量：
56.5kDa
细胞定位：

形式：
Liquid
参考文献：
van der Velden, L.A., et al. 1993. Cytokeratin expression in normal and (pre) malignant head and neck epithelia: an overview. Head Neck 15: 133-146
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality Cytokeratin 10 (KRT10) (Suprabasal Epithelial Marker) antibody - With BSA and Azide.
功能：

总结：
This MAb recognizes a protein of 56.5kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.
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