Prealbumin Antibody

分子量：
15887 Da
细胞定位：
Antigen Cellular Localization:Secreted. Cytoplasm.
形式：
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
参考文献：
1. Blake CC, et al. Nature. 268(5616):115-20, 1977
2. Klabunde T, et al. Nat Struct Biol. 7(4):312-21, 2000
3. Herbert J, et al. Neurology 36(7):900-11, 1986
4. Saraiva MJ Hum Mutat. 17(6):493-503, 2001

产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality Prealbumin antibody.
功能：
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
总结：
Transthyretin (prealbumin/TTR) is a hormone-binding protein that participates in the plasma transport of both thyroxine and retinol (vitamin A). Transthyretin concentrations are disproportionately high in human ventricular CSF. It is reported to be either selectively transported across or synthesized within the blood-CSF barrier (3). Over 80 different disease-causing mutations in transthyretin have been reported. The vast majority is inherited in an autosomal dominant manner and is related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart. A small portion of transthyretin mutations are apparently non-amyloidogenic (4). The human amyloid disorders, familial amyloid polyneuropathy, familial amyloid cardiomyopathy and senile systemic amyloidosis, are caused by insoluble transthyretin fibrils (2). Transthyretin has a structural complementarity to double-helical DNA, where the proposed binding site is composed of two symmetry-related beta-sheets containing a pair of helically disposed arms (1).
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