Phospho-Thr53 Dopamine Transporter (DAT) Antibody

分子量：
55 KDa
细胞定位：

形式：
Prepared from rabbit serum by affinity purification via sequentialchromatography on phospho- and dephosphopeptide affinity columns.
参考文献：
Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, HaycockJW (2001) Striatal dopaminergic and serotonergic markers in human heroin users.Neuropsychopharmacology 24:561-567.Wilson JM, Kalasinsky KS, Levey AI, Bergeron C, Reiber G, Anthony RM, Schmunk GA, Shannak K,Haycock JW, Kish SJ (1996) Striatal dopamine nerve terminal markers in human, chronicmethamphetamine users. Nat Med 2:699-703.Zhu MY, Klimek V, Haycock JW, Ordway GA (2000) Quantitation of tyrosine hydroxylase protein in thelocus coeruleus from postmortem human brain. J Neurosci Meth 99:37-44.Zhu MY, Klimek V, Dilley GE, Haycock JW, StockmeierC, Overholser JC, Meltzer HY, Ordway GA (1999)Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression. Biol Psychiatry46:1275-1286.James D. Foster, Jae-Won Yang, Amy E. Moritz, Sathyavathi ChallaSivaKanaka, Margaret A. Smith,Marion Holy, Kyle Wilebski, Harald H. Sitte, and Roxanne A. Vaughan (2012) Dopamine TransporterPhosphorylation Site Threonine 53 Regulates Substrate Reuptake and Amphetamine-stimulated Efflux.Journal of Biological Chemistry 287(35):29702-29712.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality Phospho-Thr53 Dopamine Transporter (DAT) antibody.
功能：

总结：
The dopamine transporter (DAT) is responsible for the reaccumulation of dopamine after it has been released. DAT antibodies and antibodies for other markers of catecholamine biosynthesis are widely used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). Levels of DAT protein expression are altered by chronic drug administration (Wilson et al., 1996). It has been shown that phosphorylation at Thr53 directly affects dopamine influx and amphetamine-stimulated substrate efflux, indicating that the Thr53 residue plays a major role in transport activity (Foster et al., 2012).
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