ENPP2 / Autotaxin Antibody (aa698-712)

分子量：
99kDa
细胞定位：
Antigen Cellular Localization:Secreted. Note=Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells
形式：
Liquid
参考文献：
Murata J.,et al.J. Biol. Chem. 269:30479-30484(1994).Kawagoe H.,et al.Genomics 30:380-384(1995).Lee H.Y.,et al.Biochem. Biophys. Res. Commun. 218:714-719(1996).van Meeteren L.A.,et al.J. Biol. Chem. 280:21155-21161(2005).Giganti A.,et al.J. Biol. Chem. 283:7776-7789(2008).
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality ENPP2 / Autotaxin antibody (aa698-712).
功能：
Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility- related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
总结：
Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility- related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
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