特别提示:包括盐酸阿霉素在内,本公司的所有产品仅可用于科研实验,严禁用于临床YL及其他非科研用途!
产品名称:盐酸阿霉素
英文名称:Doxorubicin hydrochloride
产品货号:L10118
产品规格:25mg|100mg|500mg|250mg|1g|5g
属性
CAS号 | 25316-40-9 |
分子式 | C27H29NO11·HCl |
分子量 | 579.98 |
熔点 | 216℃ |
敏感性 | 对光和湿度敏感 |
溶解性 | 溶于水、DMSO、四氢呋nán和醇,不溶于丙tóng、苯、lǜ仿、乙mí。水中溶解度:10mg/mL,水溶液为橙红色透明溶液。, |
存贮条件 | 储存温度:2-8℃ |
描述
应用 | 抗肿瘤抗生素,在心脏线粒体DNA方面有阿霉素的效果。反相转录酶和RNA聚合酶的YZ剂,免疫YZ剂;可插入DNA链中。临床上是癌症化疗剂、主要用于急、慢性白血病、恶性淋巴瘤。 |
产品介绍 | Doxorubicin(Adriamycin)是一种抗生素类试剂,YZDNA拓扑异构酶II,且诱导DNA损伤和凋亡。 |
合法信息 | Adriamycin is a registered trademark of RDF Pharmacia & Upjohn S.P.A. |
生化机理 | Doxorubicin hydrochloride is a DNA intercalator and powerful cytotoxic agent.Once it associates with the DNA groove,a covalent linkage forms between a DNA base and the pendant sugar of the small molecule.The intercalation into DNA blocks the replication of DNA by blocking Topo II(Topoisomerase II) This general mechanism gives it efficacy in a wide range of different cell types.Additionally,the expression of the oncogenes c-Myc and c-Jun is also down regulated by the chemical and a significant correlation was reported between the level of expression of these genes and the degree of cell growth inhibition conferred by Doxorubicin.Doxorubicin hydrochloride is an inhibitor of AMPK,TERT and POLR. |
别名 | 盐酸多柔比星,羟基柔红霉素盐酸盐,DOX多柔比星?盐酸盐;Adriamycin hydrochloride;DOX;Hydroxydaunorubicin hydrochloride |
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盐酸阿霉素试剂(25316-40-9)(98%),DOX,Hydroxydaunorubicin hydrochloride,Adriamycin hydrochloride,盐酸多柔比星,羟基柔红霉素盐酸盐,DOX多柔比星?盐酸盐质量上佳,价格普惠,欢迎广大新老客户踊跃订购。
温馨提示:不可用于临床ZL。