Collagen Type I| Collagen Type I antibody

Product Name Collagen Type I antibody

Catalog No PAab09910

Packing 100ul

Form liquid

Alternative Name Alpha 2 type I collagen, COL1A2, Collagen alpha 2(I) chain, Collagen Type I, collagen, type I, alpha 2, OI4

Purification protein A+G purified

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG1

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Immunogen collagen, type I, alpha 2

Specificity Human

Tested Application ELISA, IHC

Recommended dilution IHC: 1:2000 - 1:8000

IHC use Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using PAab09910( COL1A2 Antibody) at dilution of 1:5000

WB use

Protein Information

Gene ID 1278

Uniprot ID P08123

Calculated MW

Research Area Stem Cells, Cardiovascular