Phospho-VEGF Receptor 2-Y1175| Phospho-VEGF Receptor 2-Y1175 antibody

Product Name Phospho-VEGF Receptor 2-Y1175 antibody

Catalog No PAab09964

Packing 100ul

Form liquid

Alternative Name CD309, Fetal liver kinase 1, FLK 1, FLK1, KDR, Kinase insert domain receptor, VEGF Receptor 2, VEGFR, VEGFR 2, VEGFR2

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.

Immunogen A phospho specific peptide corresponding to residues surrounding Y1175 of human VEGF Receptor 2

Specificity Human, Mouse, Rat

Tested Application ELISA, WB, IHC

Recommended dilution WB: 1:500 - 1:1000; IHC: 1:50 - 1:100

IHC use Immunohistochemistry of paraffin-embedded human breast carcinoma tissue slide using PAab09964 at dilution of 1:50

WB use

HUVE cells were subjected to SDS PAGE followed by western blot with PAab09964 at dilution of 1:600

Protein Information

Gene ID 3791

Uniprot ID P35968

Calculated MW 250 kDa

Research Area